教育背景
1987-1991：内蒙古師範大學生物系讀本科，獲理學學士學位
1996-1999：澳门京葡娱乐网生命科學學院讀碩士，獲理學碩士學位
2001-2004：日本帝京科學大學環境與材料科學系讀博士，獲理學博士學位
工作經曆
1999-2001：澳门京葡娱乐网，講師
2004-2005：日本北見工業大學，博士後研究員
2005-2008：美國University of Massachusetts Medical School，博士後研究員
2008-2012：美國Sanford Burnham Prebys Medical Discovery Institute，專職研究員
2012-至今：澳门京葡娱乐网，教授
研究領域
核酸類藥物遞送；脂質體及脂質納米微球；天然多糖及蒙藥作用機制；
研究項目
國家自然科學基金委員會，面上項目，21875124，基于凝膠多糖的多功能細胞支架的設計及其抗腫瘤免疫治療活性的研究，2019-01-2022-12，65萬，在研，主持；
國家自然科學基金委員會，地區科學項目，32160231，雙配體功能化LNP載體的設計及其膠質細胞靶向siRNA遞送研究，2022-01-2025-12，34萬，在研，主持；
國家自然科學基金委員會，面上項目，21375058，利用親和光交聯和納米微粒檢測microRNA靶基因的研究，2014-01-2017-12，80萬，已結題，主持；
國家自然科學基金委員會，地區科學項目，21364006，利用分支多肽型納米微粒靶向性傳送siRNA的研究，2014-01-2017-12，50萬，已結題，主持；
國家自然科學基金委員會，地區科學項目，81560568，降血脂活性天然産物荜茇甯特異性靶标的确定及其作用機理研究，2016-01-2019-12，42萬，已結題，主持；
内蒙古自治區自然科學基金項目，2021MS02009，基于多糖型納米微球的靶向性siRNA藥物載體的設計，2021-01-2023-12，7萬，在研，主持；
内蒙古自治區科技計劃項目，額爾頓烏日勒和薩烏日勒對神經再生相關基因表達的調控作用研究，2015-01-201-/12，主要參與人，已結題；
内蒙古自治區自然科學基金項目，薩烏日勒優化方對神經細胞的保護作用機理研究，2017-01-2019-12，主要參與人，已結題；
獎勵
中共内蒙古自治區委員會組織部2013年、2018年“草原英才”獎
内蒙古自治區蒙醫藥學會腦病專業委員會2018年學術年會論文一等獎
中國民族醫藥學會2019年科學技術獎二等獎
兼職
内蒙古自治區蒙醫藥學會腦病專業委員會委員
中國民族醫藥學會腦病分會常務理事
學術期刊BioMed Research International學術編輯
研究成果（論文）
2012年-至今
1. Bao Q, Ganbold T, Qiburi Q, Bao M, Han S, Baigude H, AMP functionalized curdlan nanoparticles as a siRNA carrier: Synthesis, characterization and targeted delivery via adenosine A2B receptor, Int. J. Biol. Macromol., 2021, 193, 866-873, doi: 10.1016/j.ijbiomac.2021.10.138. (通訊作者)
2. Muqier M, Xiao H, Yu X, Li Y, Bao Q, Han S, Baigude H. Synthesis of PEGylated cationic curdlan derivatives with enhanced biocompatibility. J Biomater Sci Polym Ed. 2022 33(4):465-480, doi: 10.1080/09205063.2021.1992589. (通訊作者)
3. Hai Xiao, Han S, Baigude H. Regulation of microglia polarization via mannose receptor-mediated delivery of siRNA by ligand-functionalized DoGo LNP. RSC Adv., 2021, 11, 32549. doi: 10.1039/d1ra04293a (通訊作者)
4. Bao M, Ehexige E, Xu J, Ganbold T, Han S, Baigude H. Oxidized curdlan activates dendritic cells and enhances antitumor immunity. Carbohydr Polym. 2021, 264:117988. doi: 10.1016/j.carbpol.2021.117988. (通訊作者)
5. Qiburi Q, Temuqile T, Baigude H. Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine. Evidence-Based Complementary and Alternative Medicine. 2021: 9920364. doi.org/10.1155/2021/9920364 (通訊作者)
6. Liao C, Han Y, Chen Z, Baigude H. The extract of black cumin, licorice, anise, and black tea alleviates OVA-induced allergic rhinitis in mouse via balancing activity of helper T cells in lung. Allergy Asthma Clin Immunol. 2021 Sep 7;17(1):87. doi: 10.1186/s13223-021-00587-6. PMID: 34493326; PMCID: PMC8424864. (通訊作者)
7. Su Z, Ganbold T, Baigude H. Analysis and Identification of Tumorigenic Targets of MicroRNA in Cancer Cells by Photoreactive Chemical Probes. Int J Mol Sci. 2020 Feb 24;21(4):1545. doi: 10.3390/ijms21041545. (通訊作者)
8. Ganbold T, Bao Q, Zandan J, Hasi A, Baigude H. Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi. ACS Appl Mater Interfaces. 2020 Mar 11;12(10):11363-11374. doi: 10.1021/acsami.9b23004. (通訊作者)
9. Ehexige E, Bao M, Bazarjav P, Yu X, Xiao H, Han S, Baigude H. Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth. Biomolecules. 2020 Feb 12;10(2):285. doi: 10.3390/biom10020285. (通訊作者)
10. Erdene-Ochir T, Ganbold T, Zandan J, Han S, Borjihan G, Baigude H. Alkylation enhances biocompatibility and siRNA delivery efficiency of cationic curdlan nanoparticles. Int J Biol Macromol. 2020 Jan 15;143:118-125. doi: 10.1016/j.ijbiomac.2019.12.048. (通訊作者)
11. Su Z, Erdene-Ochir T, Ganbold T, Baigude H. Design of curdlan-based pH-sensitive polymers with endosome buffering functionality for siRNA delivery. Int J Biol Macromol. 2020 Mar 1;146:773-780. doi: 10.1016/j.ijbiomac.2019.10.129. (通訊作者)
12. Qiburi Q, Ganbold T, Bao Q, Da M, Aoqier A, Temuqile T, Baigude H. Bioactive components of ethnomedicine Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia. J Ethnopharmacol. 2020 Jan 10;246:112241. doi: 10.1016/j.jep.2019.112241. (通訊作者)
13. Ehexige E, Ganbold T, Yu X, Han S, Baigude H. Design of Peptidomimetic Functionalized Cholesterol Based Lipid Nanoparticles for Efficient Delivery of Therapeutic Nucleic Acids. Molecules. 2019 Sep 19;24(18). pii: E3413. doi: 10.3390/molecules24183413. (通訊作者)
14. Wang X, Qi Y, Liu L, Ganbold T, Baigude H, Han J. Preparation and cell activities of lactosylated curdlan-triornithine nanoparticles for enhanced DNA/siRNA delivery in hepatoma cells. Carbohydr Polym. 2019 Dec 1;225:115252. doi: 10.1016/j.carbpol. 2019.115252. Epub 2019 Aug 27. (通訊作者)
15. Ganbold T, Han S, Hasi A, Baigude H. Receptor-mediated delivery of therapeutic RNA by peptide functionalized curdlan nanoparticles. Int J Biol Macromol. 2019 Apr 1;126:633-640. doi: 10.1016/j.ijbiomac.2018.12.152. Epub 2018 Dec 18. (通訊作者)
16. Chen X, Tian F, Li M, Xu H, Cai M, Li Q, Zuo X, Wang H, Shi X, Fan C, Baigude H, Shan Y. Size-Independent Transmembrane Transporting of Single Tetrahedral DNA Nanostructures. Glob Chall. 2019 Nov 20;4(3):1900075. doi: 10.1002/gch2.201900075. PMID: 32140254; PMCID: PMC7050086.
17. Ganbold T, Baigude H. Design of Mannose-Functionalized Curdlan Nanoparticles for Macrophage-Targeted siRNA Delivery. ACS Appl Mater Interfaces. 2018, 10(17):14463-14474. (通訊作者)
18. Han S, Ganbold T, Bao Q, Yoshida T, Baigude H. Sugar Functionalized Synergistic Dendrimers for Biocompatible Delivery of Nucleic Acid Therapeutics. Polymers. 2018, 10(9), 1034 (通訊作者)
19. Gaowa S, Bao N, Da M, Qiburi Q, Ganbold T, Chen L, Altangerel A, Temuqile T, Baigude H. Traditional Mongolian medicine Eerdun Wurile improves stroke recovery through regulation of gene expression in rat brain. J Ethnopharmacol. 2018, 222:249-260. (通訊作者)
20. Dong J, Hu J, Baigude H, Zhang H. A novel ferrocenyl-naphthalimide as a multichannel probe for the detection of Cu(ii) and Hg(ii) in aqueous media and living cells. Dalton Trans. 2018 Jan 2;47(2):314-322. doi: 10.1039/c7dt03982d.
21. Gao X, Hai X, Baigude H, Guan W, Liu Z. Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport. Sci Rep. 2016 Nov 23;6:37705. doi: 10.1038/srep37705.
22. Gerile G, Ganbold T, Li Y, Baigude H. Head group configuration increases biocompatibility of cationic lipids for nucleic acids delivery, Journal of Materials Chemistry B, 2017, 5: 5597-5607. (通訊作者)
23. Tong Y, Ganbold T, Baigude H. Synthesis of Amphoteric Curdlan Derivatives for Delivery of Therapeutic Nucleic Acids, Carbohydrate Polymers, 2017, 175: 739-745. (通訊作者)
24. Han J, Wang X, Liu L, Li D, Suyaola S, Wang T, Baigude H. "Click" chemistry mediated construction of cationic curdlan nanocarriers for efficient gene delivery. Carbohydr Polym. 2017, 163:191-198. (通訊作者)
25. Ganbold T, Gerile G, Xiao H, Baigude H. Efficient in vivo siRNA delivery by stabilized D-peptide-based lipid nanoparticles. RSC Adv., 2017, 7, 8823-8831. (通訊作者)
26. Hou X, Ganbold T, Baigude H. Synthesis of biocompatible amino acid-modified poly(acrylic acid) derivatives for intracellular gene delivery, International Journal of Polymeric Materials and Polymeric Biomaterials, 2017, 67:3, 174-180 (通訊作者)
27. Altangerel A, Cai J, Liu L, Wu Y, Baigude H, Han J. PEGylation of 6-amino-6-deoxy curdlan for efficient in vivo siRNA delivery. Carbohydr Polym. 2016, 141:92-8. (通訊作者)
28. Xiao H, Altangerel A, Gerile G, Wu Y, Baigude H. Design of Highly Potent Lipid-Functionalized Peptidomimetics for Efficient in Vivo siRNA Delivery. ACS Appl Mater Interfaces. 2016, 8(12):7638-45. (通訊作者)
29. Wu Y, Cai J, Han J, Baigude H. Cell Type-Specific Delivery of RNAi by Ligand-Functionalized Curdlan Nanoparticles: Balancing the Receptor Mediation and the Charge Motivation. ACS Appl Mater Interfaces. 2015, 7(38):21521-8.（通訊作者）
30. Han J, Cai J, Borjihan W, Ganbold T, Rana TM, Baigude H. Preparation of Novel Curdlan Nanoparticles for Intracellular siRNA Delivery. Carbohydrate Polymers, 2015, 117, 324–330.（通訊作者）
31. Yu S, Gao X, Baigude H, Hai X, Zhang R, Gao X, Shen B, Li Z, Tan Z, Su H. Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging. 2015, ACS Appl Mater Interfaces. 7(9):5089-96.
32. McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana TM, Kavallaris M. Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer. Oncotarget. 2014, 6(14):12020-34.
33. Baigude H, Rana TM. Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond), 2014, 9(16), 2545-55.
34. Sarnaizul E, Borjihan G, Baigude H et al. LC analysis and pharmacokinetic study of synthetic piperlonguminine in rat plasma after oral administration. Biomed Chromatogr. 2013, 27(7), 821-4.
2012年以前：
1. Huricha Baigude, Jie Su, Joshua McCarroll, and Tariq M. Rana (2013). In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med. Chem. Lett., DOI: 10.1021/ml4001003.
2. Huricha Baigude, Ahsanullah, Zhonghan Li, Ying Zhou, and Tariq Rana (2012). miR-TRAP: a Benchtop Chemical Biology Strategy to Identify microRNA Targets. Angew. Chem. Int. Ed. 51, 5880 -5883.
3. Huricha Baigude, Tariq Rana (2012). Interfering nanoparticles for microRNA delivery. Methods in Enzymology. 509, 339-53.
4. Huricha Baigude*, Joshua McCarroll*, Chao-shun Yang, Tariq M. Rana (2010). Nanotubes Functionalized with Lipids and Natural Amino Acid Dendrimers: A New Strategy to Create Nanomaterials for Delivering Systemic RNAi.Bioconjugate Chem.21, 56-63.
5. Huricha Baigude, Tariq M. Rana (2009). Delivery of Therapeutic RNAi by Nanovehicles. ChemBioChem 10, 2449-2454.
6. Huricha Baigude, Joshua McCarroll, Chao-shun Yang, Pamela M. Swain, and Tariq M. Rana (2007). Design and Creation of New Nanomaterials for Therapeutic RNAi. ACS Chemical Biology, 2(4), 237-241.
7. Huricha Baigude, Kaname Katsuraya, Shinichi Tokunaga, Naohiko Fujiwara, Masaya Satoyama, Tomohiro Magome, Kohsaku Okuyama, Gereltu Borjihan, Toshiyuki Uryu (2005). Synthesis of an oligosaccharide-polylysine dendrimer with reducing sugar terminals leading to acquired immunodeficiency syndrome vaccine preparation. J. Polym. Sci. A Polym. Chem., 43, 2195-2206.
8. Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Naoki Kariya, and Toshiyuki Uryu (2004). Synthesis of HIV Vaccine Model Based on Lactose-Functionalized Poly(lysine) Dendrimer Scaffold. Sen’i Gakkaishi, 60, 118-124.
9. Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Kenichi, Hatanaka, Emi Ikeda, Naokazu Shibata, and Toshiyuki Uryu (2004). Synthesis of Spherical and Hemispherical Sugar-Containing Poly(ornithine) Dendrimers. J. Polym. Sci. A Polym. Chem., 42, 1400-1414.
10. Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, and Toshiyuki Uryu (2004). Synthesis of Structurally-Controlled HIV Vaccine Model Having Glyco-Peptide Dendrimer Scaffolds” Macromol. Chem. Phys., 205, 684-691. Cited by 31
11. Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Shinichi Tokunaga, and Toshiyuki Uryu (2003). Synthesis of Sphere-Type Monodispersed Oligosaccharide Polypeptide Dendrimers. Macromolecules, 36, 7100-7106.
12. Huricha Baigude, Kaname Katsuraya, Kohsaku Okuyama, Yoshihide Yachi, Shoma Sato, and Toshiyuki Uryu (2002). Synthesis of Dicarboxylate Oligosaccharide Multilayer Terminal Functionality upon Poly(lysine) Dendrimer Scaffolding. J. Polym. Sci. A Polym. Chem., 40, 3622-3633.
13. Jie Su, Huricha Baigude, Joshua McCarroll and Tariq M. Rana (2011). Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Research, 39(6), e38, doi:10.1093/nar/gkq1307.
14. Animesh Ghosh, Koushik Mukherjee, Xinpeng Jiang, Ying Zhou, Joshua McCarroll, James Qu, Pamela M. Swain, Huricha Baigude, and Tariq M. Rana (2010). Design and Assembly of New Nonviral RNAi Delivery Agents by Microwave-Assisted Quaternization (MAQ) of Tertiary Amines.Bioconjugate Chem.21 (9), 1581–1587.
15. Hongyan Wang, Animesh Ghosh, Huricha Baigude, Chao-shun Yang, Linghua Qiu, Xugang Xia, Hongxia Zhou, Tariq M. Rana and Zuoshang Xu (2008). Therapeutic Gene Silencing Delivered by A Chemically Modified siRNA Against Mutant SOD1 Slows ALS Progression J. Biol. Chem., 283, 15845-15852.
研究成果（發明專利）：
發明創造名稱：“一種陽離子脂質類化合物及其制備方法與應用”，專利号：ZL201510228936.4，發明人：胡日查，海小
發明創造名稱：“一種含有二肽類脂質陽離子的化合物及其制備方法與應用”，專利号：ZL201510228170.X，發明人：胡日查，海小
發明創造名稱：“一種基于黑種草的降血糖組合物以及降血糖蒙藥”，專利号：ZL201711071958.X，發明人：胡日查，鮑明明
發明創造名稱：“一種陽離子多糖及其制備方法與應用”，專利号：ZL202110263793.6，發明人：胡日查，清明
5. 發明創造名稱：“一種單糖配體功能化的陽離子脂質類化合物及其制備方法與應用”，申請号：202110553801.0，發明人：胡日查，海小
