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     韓淑琴

        博士, 副教授,碩士生導師

       辦公室:南校區化學樓217

       郵箱:chem-hshq@imu.edu.cn





 

教育背景

1996-2000:内蒙古師範大學 化學系本科,獲理學學士學位

2000-2003:澳门京葡娱乐网 碩士研究生,獲理學碩士學位

2004-2007:日本北見工業大學 工學部 博士研究生,獲工學博士學位

 

工作經曆

2007-2008:日本北見工業大學 博士後

2009-2010:澳门京葡娱乐网 講師

2011-至今:澳门京葡娱乐网 副教授

 

研究領域

1.      基因遞送載體的設計制備及性能研究

2.      蒙藥化學成分的鑒定與生物活性研究

 

教學

主講澳门京葡娱乐网《無機化學實驗》課程,研究生《無機物波譜學》課程,生命科學學院《大學化學1》課程

 

研究項目

1. 内蒙古自治區自然科學基金面上項目,2019MS02009, -肽樹枝狀大分子 基因載體的制備及其基因遞送功能研究,2019/09- 2022/1210萬,在研,主持

2. 國家自然科學基金面上,21875124,基于凝膠多糖的多功能細胞支架的設計及其抗腫瘤免疫治療活性的研究,2019/01-2022/1265萬,在研,參與

3. 國家自然科學基金青年,51103067ATRP法制備葫蘆脲[6]接枝殼聚糖智能藥物載體及其非供價鍵表面修飾研究,2012/01-2014/1225萬,已結題,參與

4. 留學回國人員啟動基金項目,112103,新型降脂化合物:水溶性胡椒酸衍生物的合成與藥效研究,2011/01-2013/124萬,已結題,主持

5. 國家自然科學基金地區,21067006,應用數據挖掘技術研究水環境中化學污染物的解析和辨識,2011/01-2013/1233萬,已結題,參與

6. 澳门京葡娱乐网博士啟動基金,Z00901252009/11-2011/125萬,已結題,主持

 

代表性成果

發表SCI期刊學術論文20餘篇。

第一作者及通訊作者論文:

1.       Mingming B., Ehexige E., Jing X., Tsogzolmaa G., Shuqin H., Huricha B., “Oxidized curdlan activates dendritic cells and enhances antitumor immunity”, Carbohydrate Polymers, 2021, 264(117988), 1-11.

2.       Qingming B., Tsogzolmaa G., Qiburi Q., Mingming B., Shuqin H., Huricha B., “AMP functionalized curdlan nanoparticles as a siRNA carrier: Synthesis, characterization and targeted delivery via adenosine A2B receptor”, International Journal of Biological Macromolecules, 2021, 193: 866-873.

3.       Muqier M., Hai X., Xiang Y., Yifeng L., Mingming B., Qingming B., Shuqin H., Huricha B., “Synthesis of PEGylated cationic curdlan derivatives with enhanced biocompatibility”, Journal of Biomaterials Science, Polymer Edition, 2021, 1: 1-16.

4.       Ehexige E., Mingming B., Purevbat B., Xiang Y., Hai X., Shuqin H., Huricha B., Silencing of STAT3 via peptidomimetic LNP mediated systemic delivery of RNAi downregulates PD-L1 and inhibits melanoma growth, Biomolecules, 2020, 10(285): 10(285): 1-13.

5.       Shuqin H., Tsogzolmaa G., Qingming B., Takashi Y., Huricha B., “Sugar functionalized synergistic dendrimers for biocompatibledelivery of nucleic acid therapeutics”, Polymers, 2018, 10(1034): 1-11.

6.       Shuqin H., Taisei K., Hideki N., Takashi Y. “Synthesis of a new amphiphilic glycodendrimer with antiviral functionality”, Carbohydrate Polymers, 2012, 90, 1061-1068.

7.       Shuqin H., Dai Y., Taisei K., Hideki N., Toshiyuki U., Takashi Y., “Sulfated oligosaccharide cluster with polylysine core scaffold as a new anti-HIV dendrimer”, Carbohydrate Polymers, 2010, 80, 1111-1115.

8.       Shuqin H., Yuji K., Kazuyuki H., Hidkki N., Takashi Y., “Ring-opening polymerization of benzylated 1, 6-anhydro-b-D-lactose and specific biological activities of sulfated (1→6)-a-D-lacto- pyranans”, Journal Polymer Science Part A: Polymer Chemistry, 2009, 47, 913-924.

9.       Shuqin H., Takashi Y., Toshiyuki U., “Synthesis of a new polylysine-dendritic oligosaccharide with alkyl spacer having peptide linkage”, Carbohydrate Polymers. 2007, 69, 436-444.

10.   Shuqin H., Huricha B., Kazuyuki H., Takashi Y., Toshiyuki U., “Synthesis of new spherical and hemispherical oligosaccharides with polylysine core scaffold”, Carbohydrate Polymers. 2007, 68, 26-34.

其它論文:

1.       Hai X., Shuqin H., Huricha B., “Regulation of microglia polarization via mannose receptor-mediated delivery of siRNA by ligand-functionalized DoGo LNP”, Journal of Biomaterials Science, Polymer Edition, 2021, 11(52), 32549-32558.

2.       Tseyenkhorloo E.O., Tsogzolmaa G., Jargalmaa Z., Shuqin H., Gereltu B., Huricha B., “Alkylation enhances biocompatibility and siRNA delivery efficiency of cationic curdlan nanoparticles”, International Journal of Biological Macromolecules, 2020, 143:118-125.

3.       Tsogzolmaa G., Shuqin H., Agula H., Huricha B., “Receptor-mediated delivery of therapeutic RNA by peptide functionalized curdlan nanoparticles”, Int J Biol Macromol., 2019,126: 633–640.

4.       Suvdmaa T., Shuqin H., Masashi K., Chunjie M., Taisei K., Hideki N., Takashi Y., “Isolation and antiviral activity of water-soluble cynomorium songaricum rupr polysaccharides”, J. Asian. Nat. Prod. Res., 2016, 18(2), 159-171.

5.       Shuqin H., Takashi Y., “Preparation of loading function of dendrimers to drug molecules and nucleic acid”, 65th SPSJ Annual Meeting Polymer Preprints, May 25, 2016, Kobe, Japan.

6.       Tegshi M., Budragchaa D., Taisei K., Hideki N., Koji I., Naoki Y., Shuqin H., Takashi Y., “Chemically sulfated natural galactomannans with specific antiviral and anticoagulant activities”, Int J Biol Macromol., 2016, 89, 415-420.

7.       Davaanyam B., Shiming B., Taisei K., Hideki N., Shuqin H., Takashi Y., “Synthetic galactomannans with potent anti-HIV activity”, Carbohydr. Polym., 2015, 130, 233-242.

8.       Li Y., Shuqin H., Uryu T., Takashi Y., Toshiyuki U., “Synthesis of new spherical polylysine oligosaccharide dendrimers with C6 methylene spacer”, Sen-I Gakkaishi, 2015, 71(1), 10-17.

9.       Tegshi M., Shuqin H., Kanamoto T, Hidkki N., Takashi Y., “Synthesis and specific influenza A virus-adsorptive functionality of alkyl curdlan sulfate-coated membrane filter”, J. Polym. Sci. Part A: Polym. Chem., 2011, 49, 3241-3247.

10.   Dai Y., Shuqin H., Narita K, Kazuyuki H., Takashi Y., “Synthesis of oligosaccharide -branched ribofuranan by ring-opening polymerization of a new anhydro ribo-trisaccharide monomer”, Macromol. Biosci., 2009, 9, 687-693.

11.   Takashi Y., Rong L., Shuqin H., Hattori K., Katsuta. T., Kei-ichi. S., Masamitsu F., “Laccase-catalyzed polymerization of lignocatechol and affinity on proteins of resulting polymers”, J. Polym. Sci. Part A: Polym. Chem., 2009, 47, 824-832.

 

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